Sotoxen 120 mg

Primary Indication

• The patient has already received at least one prior systemic cancer treatment (like chemotherapy or immunotherapy).
• An FDA-approved test (or equivalent genetic test) confirms the tumor has a specific genetic anomaly known as a KRAS G12C mutation.

How it Works

• The Problem: The KRAS gene normally helps regulate cell growth. When it mutates into the KRAS G12C variant, it acts like a broken cellular switch that is permanently stuck in the “on” position, signaling the lung cancer cells to rapidly multiply and survive.
• The Solution: Sotorasib physically attaches to this abnormal KRAS G12C protein and irreversibly locks it in the inactive, or “off,” position. This shuts down the faulty signaling pathway, which helps slow down or stop the spread of the cancer cells.

Standard Dosage & Administration

• Standard Dose: The typical recommended dosage is 960 mg once daily. Because Sotoxen comes in 120 mg tablets, a full daily dose usually requires taking eight tablets at once.
• Timing: It should be taken at the same time every day, and can be consumed with or without food.
• Intake: The tablets must be swallowed whole. They should never be chewed, crushed, or split. If a patient has difficulty swallowing, the tablets can be dispersed in a small glass of non-carbonated room-temperature water.
• Missed Dose: If a dose is missed by more than 6 hours, it should be skipped for the day. Patients should not take a double dose to make up for a missed one.

Important Precautions

• Drug Interactions: Sotorasib can interact with several common medications. Specifically, antacids or proton-pump inhibitors (drugs that reduce stomach acid) can affect how well the body absorbs Sotorasib.
• Monitoring: Doctors will typically monitor the patient’s liver function closely, as liver problems are a known potential risk of this medication.
• Pregnancy: It is not recommended for use during pregnancy or while breastfeeding due to potential risks to the infant.